Organ Attack Review: Strategic Party Card Game with Attack and Defense

Organ Attack is an absolute must-play if you love games that are quick, strategic, and packed with ridiculous moments. Whether you’re the kind of player who plots ahead or one who just enjoys watching the chaos unfold, there’s something undeniably entertaining about systematically removing your friends’ vital organs while trying to protect your own.

The game is beautiful and cute at the same time. Right away, the artwork sets the tone. The box, covered in Awkward Yeti’s signature illustrations, hints at the chaos within—panicked hearts, mischievous kidneys, and lungs that just look so done with life. The game comes with a deck of attack and defense cards, organ cards and rule cards.

The moment you lay eyes on these cards, you know you’re in for a good time. The expressive, slightly terrified organs really make it personal. You don’t just lose a stomach—you feel bad about it.

The rules are delightfully simple, which means you can jump into the fun without reading a medical textbook. Each player starts with a full set of organs, bravely awaiting their inevitable destruction. On your turn, you draw and play as many attack cards(above) as you like, targeting specific organs in your opponents’ bodies. Players can defend themselves with immunity cards or cunning strategy—if they’re lucky. The game continues until only one person has at least one organ left, making them the ultimate survivor.

Attacks range from mild inconveniences like kidney stones to full-on devastation, like lung cancer, which cruelly removes both lungs at once. There are no mercy rules here—if someone gets the chance to take out your muscles, they will.

Every turn is a mix of strategy and utter chaos. Do you focus on eliminating one player as quickly as possible? Do you spread your attacks and weaken everyone? Or do you play defensively, hoping to hold out long enough for the others to destroy each other first?

One of the best parts of Organ Attack is the social side of it. The table talk is half the fun. While playing we heard, You took my Esophagus? What kind of monster are you? or Look, you don’t need a gallbladder. Just let me have this one.

There’s no perfect strategy, no guaranteed way to win. Sometimes, you just have to hope that the person sitting next to you is too focused on someone else’s organs to notice that you still have a working stomach. Other times, you get targeted so aggressively that you spend half the game organ-less and bitter, plotting revenge in your next match. There are a few cards, like the one below that take a player out of the mix….use these strategicly.

So, have you played Organ Attack? Were you victorious, or did you fall victim to an especially well-timed gallbladder removal? Share your best stories, and let’s compare notes—because nothing brings people together quite like laughing over brutal organ failure in card game form.

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